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A phase 2 trial of irinotecan (and liposomal irinotecan), tislelizumab and capecitabine in colorectal cancer, run by Affiliated Cancer Hospital of Shantou University Medical College, now recruiting.
Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Tislelizumab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement is a phase 2, interventional study registered as NCT07104604 by Affiliated Cancer Hospital of Shantou University Medical College, with a registry enrolment figure of 51 participants, started 2025-10-20 and due to reach its primary completion in 2027-03-31. Interventions recorded: Liposomal Irinotecan+Tislelizumab+Capecitabine+Rradiotherapy. Conditions listed: Rectal Cancer. Primary outcome: Complete response (CR) rate. Colorectal eligibility wording from the registry: "* Biopsy-confirmed pMMR (proficient mismatch repair) localized advanced low rectal adenocarcinoma (tumor's lower edge ≤ 10 cm from the anus)". Sites: China. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Irinotecan (and liposomal irinotecan), Topoisomerase-I inhibitors (and ADC payloads), Capecitabine, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Tislelizumab, Capecitabine, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Tislelizumab, Capecitabine, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Tislelizumab, Capecitabine, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Tislelizumab, Capecitabine, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Capecitabine, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Tislelizumab, Topoisomerase-I inhibitors (and ADC payloads), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Irinotecan (and liposomal irinotecan), Topoisomerase-I inhibitors (and ADC payloads), Capecitabine, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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