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A phase 2 trial of botensilimab and balstilimab in colorectal cancer, run by Weill Medical College of Cornell University, now recruiting.
Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases is a phase 2, randomised interventional study registered as NCT06300463 by Weill Medical College of Cornell University, with a registry enrolment figure of 24 participants, started 2024-03-26 and due to reach its primary completion in 2026-12. Interventions recorded: Botensilimab; Balstilimab; AGEN1423; Radiation. Conditions listed: Colorectal Cancer Metastatic; Liver Metastases; Colorectal Cancer. Primary outcome: Mean CD8:Treg ratio, as determined by flow cytometry of tumor tissue, at time of surgical resection in each treatment arm. Colorectal eligibility wording from the registry: "* Diagnosis of metastatic colorectal adenocarcinoma with liver metastases". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Agenus, Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Agenus, Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Agenus, Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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