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A phase 2 trial of balstilimab and botensilimab in colorectal cancer, run by National Cancer Institute (NCI), now recruiting.
Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial is a phase 2, interventional study registered as NCT07551596 by National Cancer Institute (NCI), with a registry enrolment figure of 20 participants, started 2027-05-25 and due to reach its primary completion in 2029-08-28. Interventions recorded: Balstilimab; Biopsy Procedure; Biospecimen Collection; Botensilimab; Radiographic Examination. Conditions listed: Colorectal Adenocarcinoma; Stage II Colorectal Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8. Primary outcome: Circulating tumor deoxyribonucleic acid (ctDNA) clearance. Colorectal eligibility wording from the registry: "* Histological confirmation of colorectal cancer (adenocarcinoma) (CRC)". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Botensilimab, Balstilimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, MRD / molecular residual disease testing, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares MRD / molecular residual disease testing, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares MRD / molecular residual disease testing, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
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