Loading
The Italian duration trial could not show that three months was as good as six, and it is the reason the pooled answer depends on which drug combination is used.
TOSCA accrued 3,759 patients with stage II or III colon cancer to three or six months of FOLFOX4 or CAPOX. At a median seven years the hazard ratio for relapse-free survival of three against six months was 1.13 (95% CI 0.99 to 1.29), crossing the prespecified non-inferiority limit of 1.20, so inferiority of the shorter arm could not be ruled out; the hazard ratio for overall survival was 1.09 (0.93 to 1.26, p=0.288 for superiority) with no significant difference between groups. TOSCA pulls against SCOT in the IDEA pooled analysis, and the difference between their regimen mixes, mostly CAPOX in SCOT and more FOLFOX in TOSCA, is part of why three months holds for CAPOX and not for FOLFOX.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares IDEA collaboration, Oxaliplatin, Neoadjuvant / adjuvant / perioperative, FOLFOX (5-FU, leucovorin, oxaliplatin).
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents, Colon cancer (adenocarcinoma of the colon).
Shares CAPOX (capecitabine, oxaliplatin), FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents.
Shares CAPOX (capecitabine, oxaliplatin), Oxaliplatin, Capecitabine, Platinum agents.
Shares CAPOX (capecitabine, oxaliplatin), Capecitabine, Platinum agents, Colon cancer (adenocarcinoma of the colon).
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents, Colon cancer (adenocarcinoma of the colon).
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents, Colon cancer (adenocarcinoma of the colon).
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents, Colon cancer (adenocarcinoma of the colon).
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/