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SJMB12 is the St. Jude trial that first treated medulloblastoma by its molecular type: children with the low-risk WNT form receive a much lower dose of radiotherapy to the brain and spine, those with the SHH form add the targeted drug vismodegib, and the others add two extra chemotherapy drugs; it is still running and the corpus records the design.
SJMB12 is a non-randomised phase 2 trial at St. Jude Children's Research Hospital and partner centres in which newly diagnosed medulloblastoma is assigned to strata by molecular subgroup (WNT, SHH, group 3 and 4) and clinical risk. Low-risk WNT patients receive craniospinal irradiation of 15 Gy with a reduced boost and four cycles of cyclophosphamide, cisplatin and vincristine; skeletally mature SHH patients add maintenance vismodegib; intermediate- and high-risk non-WNT, non-SHH patients add pemetrexed and gemcitabine. Randomised sub-studies test aerobic training and cognitive remediation. The primary endpoints are progression-free survival at two years in the low-risk WNT, standard-risk SHH and standard-risk group 3 and 4 strata.
The registry lists 660 participants with a primary completion date of October 2028 and no posted results. The corpus's WNT medulloblastoma page cites SJMB12 for 15 Gy craniospinal radiotherapy alongside the COG ACNS1422 study of 18 Gy.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares WNT-activated medulloblastoma, Brain and spinal cord tumours (all types), Medulloblastoma, Childhood cancers (all types) and the tag soc-trials.
Shares Brain and spinal cord tumours (all types), Childhood cancers (all types), Vincristine, Cyclophosphamide and the tag soc-trials.
Shares Brain and spinal cord tumours (all types), Childhood cancers (all types), Vincristine, Cyclophosphamide and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Cyclophosphamide, IMRT / IGRT (modern external beam) and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Cyclophosphamide, Cisplatin and the tag soc-trials.
Shares Brain and spinal cord tumours (all types), Childhood cancers (all types), IMRT / IGRT (modern external beam), Cytotoxic chemotherapy and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Cyclophosphamide, Cytotoxic chemotherapy and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Cyclophosphamide, Cytotoxic chemotherapy and the tag soc-trials.
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