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EuroNet-PHL-C2 is the huge European trial that treats children with Hodgkin lymphoma using PET scans after the first two cycles to decide who can skip radiotherapy, and tests a more intensive chemotherapy consolidation to make that possible for more of them; enrolment of nearly 3,000 children has closed and the full results are awaited.
EuroNet-PHL-C2 was the second international inter-group study of the European Network for Paediatric Hodgkin Lymphoma, sponsored by the University of Giessen, enrolling 2,921 children and adolescents with classical Hodgkin lymphoma between 2015 and 2024. All patients received OEPA induction (vincristine, etoposide, prednisone, doxorubicin) with an early PET response assessment. Intermediate- and advanced-stage patients were randomised to COPDAC-28 consolidation (cyclophosphamide, vincristine, prednisone, dacarbazine) or the intensified DECOPDAC-21 (adding etoposide and doxorubicin), with radiotherapy omitted in adequate early responders and restricted to residual PET-positive sites otherwise. The primary endpoint is five-year event-free survival.
The registry records the trial as completed in October 2025 with no posted results, and no primary publication was found on Europe PMC by NCT id, so the record states the design. The corpus's Hodgkin lymphoma page cites the trial for risk-adapted OEPA/COPDAC with PET-guided radiotherapy omission.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Childhood cancers (all types), Prednisone, Vincristine, Etoposide and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Etoposide, Cyclophosphamide and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Etoposide, Doxorubicin and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Etoposide, Doxorubicin and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Cyclophosphamide, IMRT / IGRT (modern external beam) and the tag soc-trials.
Shares Childhood cancers (all types), Vincristine, Etoposide, Cyclophosphamide and the tag soc-trials.
Shares Prednisone, Vincristine, Doxorubicin, Cyclophosphamide and the tag soc-trials.
Shares Childhood cancers (all types), Etoposide, Doxorubicin, Cyclophosphamide and the tag soc-trials.
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