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A phase 3 trial of bevacizumab (glioblastoma use), fluorouracil (5-FU), irinotecan (and liposomal irinotecan), leucovorin (folinic acid) and other drugs in colorectal cancer, run by City of Hope Medical Center, not yet recruiting.
Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial is a phase 3, randomised interventional study registered as NCT07271355 by City of Hope Medical Center, with a registry enrolment figure of 129 participants, started 2026-10-01 and due to reach its primary completion in 2031-02-28. Interventions recorded: Bevacizumab; Biopsy Procedure; Biospecimen Collection; Computed Tomography; Fluorouracil; Irinotecan Hydrochloride; Leucovorin Calcium; Magnetic Resonance Imaging; Mitomycin; Questionnaire Administration. Conditions listed: Metastatic Appendix Carcinoma; Metastatic Colorectal Carcinoma; Metastatic Malignant Neoplasm in the Peritoneum; Stage IV Appendix Carcinoma AJCC v8; Stage IVC Colorectal Cancer AJCC v8; Unresectable Colorectal Carcinoma. Primary outcome: Overall survival (OS). Colorectal eligibility wording from the registry: "* Histologically or cytologically confirmed appendiceal or colorectal cancer peritoneal metastases". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Irinotecan (and liposomal irinotecan), Bevacizumab (glioblastoma use), Leucovorin (folinic acid), Fluorouracil (5-FU) and the tag colorectal-deep-dive.
Shares Irinotecan (and liposomal irinotecan), Bevacizumab (glioblastoma use), Leucovorin (folinic acid), Fluorouracil (5-FU) and the tag colorectal-deep-dive.
Shares Bevacizumab (glioblastoma use), Leucovorin (folinic acid), Fluorouracil (5-FU), Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Bevacizumab (glioblastoma use), Leucovorin (folinic acid), Fluorouracil (5-FU), Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Irinotecan (and liposomal irinotecan), Bevacizumab (glioblastoma use), Leucovorin (folinic acid), Fluorouracil (5-FU) and the tag colorectal-deep-dive.
Shares Irinotecan (and liposomal irinotecan), Bevacizumab (glioblastoma use), Topoisomerase-I inhibitors (and ADC payloads), Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Irinotecan (and liposomal irinotecan), Bevacizumab (glioblastoma use), Topoisomerase-I inhibitors (and ADC payloads), Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Mitomycin C, HIPEC / PIPAC (intraperitoneal chemotherapy), Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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