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A phase 2/3 trial of topotecan in lung cancer, run by Peking Union Medical College Hospital, not yet recruiting.
Organoid-guided vs Topotecan Therapy in Relapsed Extensive-Stage Small Cell Lung Cancer is a phase 2/3, randomised interventional study registered as NCT07106528 by Peking Union Medical College Hospital, with a registry enrolment figure of 128 participants, started 2025-08 and due to reach its primary completion in 2027-12. Interventions recorded: Organoid Drug Sensitivity Testing-Guided Therapy; Topotecan. Conditions listed: Extensive-stage Small Cell Lung Cancer (ES-SCLC); Extensive-stage Small Cell Lung Cancer (SCLC); Small Cell Lung Cancer ( SCLC ). Primary outcome: Progression-Free Survival (PFS). Lung eligibility wording from the registry: "Pathologically confirmed extensive-stage small cell lung cancer (ES-SCLC) (AJCC 9th edition, Stage IV)". No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Topotecan, Extensive-stage small-cell lung cancer, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot), Cytotoxic chemotherapy and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot), Cytotoxic chemotherapy and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Lung cancer trials open today (registry snapshot), Cytotoxic chemotherapy and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot), Cytotoxic chemotherapy and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot), Cytotoxic chemotherapy and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
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