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A phase 2 trial of durvalumab, monalizumab and etoposide in lung cancer, run by Hirva Mamdani, now recruiting.
MOnaliZumab in Combination With durvAlumab (MEDI4736) for tRreatmenT of Small Cell Lung Cancer is a phase 2, interventional study registered as NCT05903092 by Hirva Mamdani, with a registry enrolment figure of 84 participants, started 2023-09-26 and due to reach its primary completion in 2029-10-31. Interventions recorded: Durvalumab; Monalizumab; Carboplatin or Cisplatin; Etoposide. Conditions listed: Small Cell Lung Cancer; SCLC; Extensive Stage Small Cell Lung Cancer; Limited Stage Small-Cell Lung Cancer. Primary outcome: 1 year Progression Free Survival (PFS); Safety and Tolerability. Lung eligibility wording from the registry: "Histologically or cytologically confirmed diagnosis of small cell lung cancer:". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Extensive-stage small-cell lung cancer, Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Monalizumab, Durvalumab, Lung cancer trials open today (registry snapshot), AstraZeneca and the tag lung-deep-dive.
Shares Limited-stage small-cell lung cancer, Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Limited-stage small-cell lung cancer, Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Extensive-stage small-cell lung cancer, Durvalumab, Lung cancer trials open today (registry snapshot), AstraZeneca and the tag lung-deep-dive.
Shares Etoposide, Durvalumab, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
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