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A phase 2 trial of sintilimab, fluorouracil (5-FU), raltitrexed, fOLFOX (5-FU, leucovorin, oxaliplatin) and other drugs in colorectal cancer, run by Fudan University, not yet recruiting.
CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRC is a phase 2, interventional study registered as NCT06652412 by Fudan University, with a registry enrolment figure of 124 participants, started 2024-11 and due to reach its primary completion in 2027-11. Interventions recorded: Ultrafractionated RT and CGA Guided systemic treatment.; data prospectively collected; Ultrafractionated Radiotherapy; Sintilimab; Fluorouracil; Raltitrexed; Oxaliplatin; Irinotecan (CPT-11). Conditions listed: Colon Cancer; Rectal Cancer. Primary outcome: Complete response (CR) rate. Colorectal eligibility wording from the registry: "Pathologically confirmed Colorectal adenocarcinoma;". No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU), Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares Raltitrexed, FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU), Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU), Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares Sintilimab, FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
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