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A phase 3 trial in colorectal cancer, run by Leiden University Medical Center, now recruiting.
DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06275958 by Leiden University Medical Center, with a registry enrolment figure of 587 participants, started 2024-07-01 and due to reach its primary completion in 2028-06. Interventions recorded: Doublet Chemotherapy, Standard Dose (100%); Doublet Chemotherapy, Dose-reduced (75%); Monotherapy, Standard Dose (100%); Monotherapy, Dose-reduced (75%). Conditions listed: Older Patients; Colorectal Cancer; Metastatic Cancer; Candidates for Palliative Chemotherapy. Primary outcome: Progression-Free Survival. Colorectal eligibility wording from the registry: "* Patients aged 70 years or older with colorectal cancer and distant metastases without localized treatment options". Sites: Netherlands. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
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