{"entity":{"id":"nct06275958","kind":"trial","name":"DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer","aka":["DOSAGE"],"tldr":"A phase 3 trial in colorectal cancer, run by Leiden University Medical Center, now recruiting.","summary":"DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06275958 by Leiden University Medical Center, with a registry enrolment figure of 587 participants, started 2024-07-01 and due to reach its primary completion in 2028-06. Interventions recorded: Doublet Chemotherapy, Standard Dose (100%); Doublet Chemotherapy, Dose-reduced (75%); Monotherapy, Standard Dose (100%); Monotherapy, Dose-reduced (75%). Conditions listed: Older Patients; Colorectal Cancer; Metastatic Cancer; Candidates for Palliative Chemotherapy. Primary outcome: Progression-Free Survival. Colorectal eligibility wording from the registry: \"* Patients aged 70 years or older with colorectal cancer and distant metastases without localized treatment options\". Sites: Netherlands. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06275958","url":"https://clinicaltrials.gov/study/NCT06275958"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06275958","phase":"3","setting":"DOSAGE Study: a Multicenter Randomized Phase III Trial of DOSe-reduced Chemotherapy for Advanced Colorectal Cancer in Older Patients","sponsor":"Leiden University Medical Center","participation":[{"nct":"NCT06275958","source":"https://clinicaltrials.gov/study/NCT06275958","fetchedAt":"2026-10-07T16:54:29.928Z","studySha256":"890ddce33acc906800f115d7ee2e0dd0bd54da0e9f3f93e0c83ef1e91a763aff","overallStatus":"RECRUITING","lastUpdatePosted":"2024-10-16","leadSponsor":"Leiden University Medical Center","collaboratorCount":1,"minimumAge":"70 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":587,"enrolmentType":"ESTIMATED","siteCount":36,"recruitingSiteCount":10,"countries":["Netherlands"]}],"started":"2024-07-01","startedType":"actual","enrolled":587,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06275958/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}