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A phase 3 trial of Sacituzumab tirumotecan, Docetaxel, Pemetrexed in non-small-cell lung cancer and small-cell lung cancer, run by Merck Sharp & Dohme LLC, active and no longer recruiting.
Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004). ClinicalTrials.gov record last updated 2026-08-14: active not recruiting. Enrollment is planned at 556 participants. Primary completion is estimated at 2027-05-10. No tabular results are posted on ClinicalTrials.gov; this does not exclude separate publications. Registered interventions: Sacituzumab tirumotecan, Docetaxel, Pemetrexed. Registered primary measures: Overall Survival (OS) of Participants with NSCLC with Epidermal Growth Factor Receptor (EGFR) Mutations.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Sacituzumab tirumotecan, TROP2, Pemetrexed, EGFR-mutated non-small-cell lung cancer.
Shares Sacituzumab tirumotecan, TROP2, Topoisomerase-I inhibitors (and ADC payloads), Merck & Co. (MSD).
Shares Sacituzumab tirumotecan, TROP2, Topoisomerase-I inhibitors (and ADC payloads), Merck & Co. (MSD).
Shares TROP2, Docetaxel, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC).
Shares Sacituzumab tirumotecan, TROP2, Pemetrexed, Topoisomerase-I inhibitors (and ADC payloads).
Shares Docetaxel, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC), Small-cell lung cancer.
Shares Sacituzumab tirumotecan, EGFR-mutated non-small-cell lung cancer, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC).
Shares Pemetrexed, Docetaxel, EGFR-mutated non-small-cell lung cancer, Small-cell lung cancer.
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