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A phase 3 trial of carboplatin, cisplatin, durvalumab, etoposide and other drugs in lung cancer, run by National Cancer Institute (NCI), active but no longer recruiting.
Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT04092283 by National Cancer Institute (NCI), with a registry enrolment figure of 660 participants, started 2020-04-29 and due to reach its primary completion in 2028-12-31. Interventions recorded: Carboplatin; Cisplatin; Durvalumab; Etoposide; Paclitaxel; Pemetrexed Disodium. Conditions listed: Recurrent Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Unresectable Lung Non-Small Cell Carcinoma. Primary outcome: Overall survival (OS). Lung eligibility wording from the registry: "* Newly diagnosed stage IIIA/B/C non-small cell lung cancer (NSCLC) (per the American Joint Committee on Cancer \[AJCC\] 8th edition) that is unresectable and is histologically and/or cytologically confirmed". Sites: Guam, United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Etoposide, Pemetrexed, Durvalumab, Topoisomerase-I inhibitors (and ADC payloads) and the tag lung-deep-dive.
Shares Unresectable stage III non-small-cell lung cancer, Etoposide, Pemetrexed, Durvalumab and the tag lung-deep-dive.
Shares Unresectable stage III non-small-cell lung cancer, Pemetrexed, Durvalumab, Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot), Platinum agents and the tag lung-deep-dive.
Shares Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot), Platinum agents and the tag lung-deep-dive.
Shares Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot), Platinum agents and the tag lung-deep-dive.
Shares Unresectable stage III non-small-cell lung cancer, Pemetrexed, Lung cancer trials open today (registry snapshot), Paclitaxel / nab-paclitaxel and the tag lung-deep-dive.
Shares Etoposide, Topoisomerase-I inhibitors (and ADC payloads), Lung cancer trials open today (registry snapshot), Platinum agents and the tag lung-deep-dive.
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