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A phase 2 trial of serplulimab, capecitabine, fOLFOX (5-FU, leucovorin, oxaliplatin) and celecoxib in colorectal cancer, run by Zhejiang University, now recruiting.
Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT05731726 by Zhejiang University, with a registry enrolment figure of 50 participants, started 2023-02-22 and due to reach its primary completion in 2026-12-30. Interventions recorded: Serplulimab; Capecitabine; Oxaliplatin; Celecoxib. Conditions listed: pMMR; MSS; MSI-L; Locally Advanced Rectal Carcinoma. Primary outcome: Pathological complete response rates. Colorectal eligibility wording from the registry: "Histological or cytological documentation of adenocarcinoma of the rectum". Sites: China. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Celecoxib, Serplulimab, FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine and the tag colorectal-deep-dive.
Shares Serplulimab, FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents and the tag colorectal-deep-dive.
Shares Serplulimab, FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents and the tag colorectal-deep-dive.
Shares Serplulimab, FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Serplulimab, FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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