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A phase 3 trial of Datopotamab deruxtecan, Pembrolizumab, Pemetrexed in non-small-cell lung cancer and small-cell lung cancer, run by Daiichi Sankyo, active and no longer recruiting.
Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07). ClinicalTrials.gov record last updated 2026-06-23: active not recruiting. Enrollment is planned at 1170 participants. Primary completion is estimated at 2029-05-11. No tabular results are posted on ClinicalTrials.gov; this does not exclude separate publications. Registered interventions: Datopotamab Deruxtecan, Pembrolizumab, Pemetrexed, Carboplatin, Cisplatin. Registered primary measures: Progression-free Survival Based on Blinded Independent Central Review in All Randomized Participants; Progression-free Survival Based on Blinded Independent Central Review in All Randomized Participants who are TROP2 NMR positive; Overall Survival in All Randomized Participants.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Datopotamab deruxtecan, TROP2, Pemetrexed, Topoisomerase-I inhibitors (and ADC payloads).
Shares TROP2, Pemetrexed, Topoisomerase-I inhibitors (and ADC payloads), Cisplatin.
Shares Datopotamab deruxtecan, TROP2, Pemetrexed, Topoisomerase-I inhibitors (and ADC payloads).
Shares Datopotamab deruxtecan, Daiichi Sankyo, TROP2, Small-cell lung cancer.
Shares Daiichi Sankyo, Pemetrexed, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC).
Shares Datopotamab deruxtecan, TROP2, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC).
Shares Pemetrexed, Topoisomerase-I inhibitors (and ADC payloads), Cisplatin, Carboplatin.
Shares Pemetrexed, Cisplatin, Carboplatin, Small-cell lung cancer.
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