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Trials
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphom

A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphom

A phase 3 trial of Zanubrutinib, Rituximab, Lenalidomide in follicular lymphoma, run by BeOne Medicines, active and no longer recruiting.

Active

Also called: MAHOGANY

Overview Taking part Connected10

Overview

A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma is a phase 3 interventional study registered as NCT05100862 by BeOne Medicines, with 799 participants enrolled, started 2022-03-10 and due to reach its primary completion in 2028-07. Interventions recorded: Zanubrutinib, Rituximab, Lenalidomide, Obinutuzumab. Conditions listed: Relapsed/Refractory Follicular Lymphoma, Marginal Zone Lymphoma. No results are recorded here; the registry entry is the source.

Setting

A Phase 3 Randomized, Open-Label Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

Phase

Phase 3

Sponsor

BeOne Medicines

Registry

Started

2022-03-10

Enrolled

799 enrolled

Taking part

NCT05100862active not recruiting

Run by: BeOne Medicines
Open to: 18 Years and over, any sex
Enrolment: 799
Sites: 264
Countries: Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Canada, China, Czechia, France, Georgia, Germany, Greece, Ireland, Israel, Italy, Japan, Poland, Portugal, Puerto Rico, Romania, South Africa, South Korea, Spain, Switzerland, Turkey (Türkiye), United Kingdom, United States
Registry updated: 2026-09-28

The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.

ClinicalTrials.gov data courtesy of the US National Library of Medicine.

Connected

10

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cancers

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)Follicular lymphoma

technologies

Monoclonal antibodies PROTACs & molecular glues (targeted protein degradation)Small-molecule kinase inhibitors

drugs

ApprovedImmunomodulatory drug (cereblon E3 ligase modulator)

Lenalidomide · Revlimid

ApprovedMonoclonal antibody (anti-CD20, glycoengineered type II)

Obinutuzumab · Gazyva

ApprovedMonoclonal antibody (anti-CD20, chimeric)

Rituximab · Rituxan / MabThera (and biosimilars)

ApprovedSmall-molecule covalent BTK inhibitor (second generation)

Zanubrutinib · Brukinsa

companies

BeOne Medicines (formerly BeiGene)

Evidence strength50/100 · Solid

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
799 enrolled+15
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

Make correction

Report a readout

Cancers

Follicular lymphoma

Technologies

Small-molecule kinase inhibitors
Monoclonal antibodies
PROTACs & molecular glues (targeted protein degradation)

Products

Zanubrutinib
Rituximab
Lenalidomide
Obinutuzumab

Companies

BeOne Medicines (formerly BeiGene)

Sources

Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.

ClinicalTrials.gov · 1

ClinicalTrials.gov NCT05100862

A source that has moved or gone is reported by the weekly link check. /audit/

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sourced, not expert-reviewed

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