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Trials
A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus

A phase 3 trial of Tazemetostat, Lenalidomide, Rituximab in follicular lymphoma, run by Epizyme, Inc., active and no longer recruiting.

Active

Also called: Symphony-1

Overview Taking part Connected8

Overview

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma. is a phase 3 interventional study registered as NCT04224493 by Epizyme, Inc., with 599 participants enrolled, started 2020-06-11 and due to reach its primary completion in 2027-02-13. Interventions recorded: Tazemetostat, Tazemetostat, Placebo oral tablet, Lenalidomide, Rituximab. Conditions listed: Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma. No results are recorded here; the registry entry is the source.

Setting

Symphony-1: A Phase 1b/3 Double-Blind, Randomized, Active-Controlled, 3-Stage, Biomarker Adaptive Study Of Tazemetostat Or Placebo In Combination With Lenalidomide Plus Rituximab In Subjects With Relapsed/Refractory Follicular Lymphoma

Phase

Phase 3

Sponsor

Epizyme, Inc.

Registry

Started

2020-06-11

Enrolled

599 enrolled

Taking part

NCT04224493active not recruiting

Run by: Epizyme, Inc.
Open to: 18 Years and over, any sex
Enrolment: 599
Sites: 204
Countries: Australia, Belgium, Brazil, Canada, China, France, Germany, Hungary, Italy, Poland, Singapore, South Korea, Spain, Taiwan, Turkey (Türkiye), United Kingdom, United States
Registry updated: 2026-10-05

The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.

ClinicalTrials.gov data courtesy of the US National Library of Medicine.

Connected

8

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Tazemetostat with doxorubicin as front-line therapy for advanced epithelioid sarcoma (EZH-301 run-in)
Shares Tazemetostat, Ipsen, Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET).

cancers

Follicular lymphoma

technologies

Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)Monoclonal antibodies PROTACs & molecular glues (targeted protein degradation)

drugs

ApprovedImmunomodulatory drug (cereblon E3 ligase modulator)

Lenalidomide · Revlimid

ApprovedMonoclonal antibody (anti-CD20, chimeric)

Rituximab · Rituxan / MabThera (and biosimilars)

WithdrawnSmall-molecule EZH2 inhibitor

Tazemetostat · Tazverik

companies

Evidence strength49/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
599 enrolled+14
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

Make correction

Report a readout

Cancers

Follicular lymphoma

Technologies

Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET)
Monoclonal antibodies
PROTACs & molecular glues (targeted protein degradation)

Products

Tazemetostat
Lenalidomide
Rituximab

Companies

Ipsen

Sources

Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.

ClinicalTrials.gov · 1

ClinicalTrials.gov NCT04224493

A source that has moved or gone is reported by the weekly link check. /audit/

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sourced, not expert-reviewed

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