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A phase 3 trial of encorafenib, binimetinib, trastuzumab and pertuzumab in colorectal cancer, run by Massachusetts General Hospital, active but no longer recruiting.
Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer is a phase 3, randomised interventional study registered as NCT03803553 by Massachusetts General Hospital, with a registry enrolment figure of 400 participants, started 2020-04-16 and due to reach its primary completion in 2026-12. Interventions recorded: FOLFIRI Protocol; ACTIVE SURVEILLANCE; Nivolumab Protocol; Encorafenib/Binimetinib/Cetuximab Protocol; Trastuzumab + Pertuzumab. Conditions listed: Metastatic Colon Cancer; Stage III Colon Cancer. Primary outcome: Disease-free survival (DFS); Clearance rate of ctDNA. Colorectal eligibility wording from the registry: "* Participants must have histologically confirmed resected Stage III adenocarcinoma of the colon". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Encorafenib, Monoclonal antibodies, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Encorafenib, Monoclonal antibodies, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Monoclonal antibodies, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Small-molecule kinase inhibitors and the tag colorectal-deep-dive.
Shares Trastuzumab, Monoclonal antibodies, Colorectal cancer trials open today (registry snapshot), Small-molecule kinase inhibitors and the tag colorectal-deep-dive.
Shares Encorafenib, Colorectal cancer trials open today (registry snapshot), Small-molecule kinase inhibitors and the tag colorectal-deep-dive.
Shares Monoclonal antibodies, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Monoclonal antibodies, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Monoclonal antibodies, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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