Telik was a Palo Alto biotech whose glutathione analogue canfosfamide (Telcyta) failed its phase 3 trials in ovarian and lung cancer in the 2000s, a reminder that late-stage failure is the norm in oncology.
Telik, Inc., founded in 1988 in Palo Alto, California, developed canfosfamide (TLK286, Telcyta), a prodrug activated by glutathione S-transferase P1-1 that is overexpressed in many tumours. It led phase 3 trials in platinum-resistant ovarian cancer and non-small cell lung cancer, none of which met their primary endpoints, and the company later wound down its programmes. Its trials remain on ClinicalTrials.gov under Telik as lead sponsor.
Shares Pivotal (registrational) trial, Clinical trial, Non-small-cell lung cancer.
Shares Pivotal (registrational) trial, Clinical trial, Cytotoxic chemotherapy.
Shares Pivotal (registrational) trial, Clinical trial, Non-small-cell lung cancer.
Shares Pivotal (registrational) trial, Clinical trial, Non-small-cell lung cancer.
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