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Achieve Life Sciences (formerly OncoGenex)
Achieve Life Sciences carries the trial record of OncoGenex, whose antisense drug custirsen failed phase 3 trials in prostate and lung cancer before the company turned to a smoking-cessation medicine.
Also called: Achieve Life Sciences, Inc.OncoGenex PharmaceuticalsOncoGenex
Overview
OncoGenex Pharmaceuticals, founded in 2000 in Bothell, Washington, developed custirsen (OGX-011), an antisense inhibitor of clusterin, and led the phase 3 SYNERGY and AFFINITY trials in metastatic castration-resistant prostate cancer and a phase 3 trial in non-small cell lung cancer, none of which improved survival. In 2017 it merged with Achieve Life Sciences, which now develops cytisinicline for smoking cessation, a cancer prevention aim. The custirsen trials sit on ClinicalTrials.gov under the Achieve name.
Headquarters
Bothell, WA, US
Scorecard
All companies#473of 1245 companies, score 5
- modalities +2
- registry trials +6
- failures -3
0 approved, 0 in phase 3, 0 earlier, 0 targets, 9 registry studies. Formula on the scorecards page.
Type
Stage
Public
Website
Founded
2000
Products
1Withdrawnantisense oligonucleotide
A drug designed to switch off a protein that helps cancer cells survive chemotherapy. Two large trials found it added nothing.
Connected
7Similar pages
- CompanyIonis Pharmaceuticals
Shares Oligonucleotide therapeutics, Prostate cancer, Non-small-cell lung cancer.
- TermProstate cancer programmes that failed, and what each failure taught
Shares AFFINITY, SYNERGY, Oligonucleotide therapeutics, Prostate cancer.
- TrialTROPIC
Shares AFFINITY, Prostate cancer.
- TrialTAX 327
Shares SYNERGY, Prostate cancer.
- TreatmentCabazitaxel
Shares AFFINITY, Prostate cancer.
- PathwayRNA splicing
cancers
fronts
technologies
drugs
Withdrawnantisense oligonucleotide
trials
Sources
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
achievelifesciences.com · 1
ClinicalTrials.gov · 1
wikidata.org · 1
A source that has moved or gone is reported by the weekly link check. /audit/
ProvenanceLast edited 2026-09-17 · Jude Gomila · Link orphan sponsor companies, repoint AAA trials to Nova… · diff · file
Sourced, not expert-reviewed