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The largest screening trial ever run for ovarian cancer found earlier detection but no reduction in deaths, so there is still no recommended screening.
Over 16 years of follow-up, multimodal screening shifted stage at diagnosis but did not reduce ovarian and tubal cancer deaths by a statistically significant margin (Lancet 2021). It is the central reason no guideline recommends population screening and why effort has moved to risk-reducing salpingectomy and multi-cancer blood tests.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
202,638 enrolled.
relative reduction, not significant
Source| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Ovarian and tubal cancer mortality reduction (multimodal vs none)primary | Multimodal screening | - | 4% | - | - | link |
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Serum tumour markers: proper use and misuse, Ultrasound, Multi-cancer early detection (MCED), The hardest cancers are found late.
Shares Surrogate endpoint, Surrogate endpoint validation: which stand-ins have earned trust, Why trials fail: underpowered, wrong endpoint, control arm drift, subgroup fishing, crossover.
Shares CA-125, Ovarian cancer.
Shares CA-125, Serum tumour markers: proper use and misuse, Ovarian cancer.
Shares Stage shift, Multi-cancer early detection (MCED), The hardest cancers are found late.
Shares Stage shift, Multi-cancer early detection (MCED), The hardest cancers are found late.
Shares Stage shift, Multi-cancer early detection (MCED), The hardest cancers are found late.
Shares Stage shift, Multi-cancer early detection (MCED), The hardest cancers are found late.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/