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SCALOP-2 is the UK follow-on to SCALOP, testing whether a higher radiotherapy dose or the HIV drug nelfinavir improves chemoradiotherapy for pancreatic cancer that cannot be removed; it finished in 2021 and its main results had not appeared in an indexed journal by September 2026.
SCALOP-2 (ISRCTN50083238, NCT02024009) recruited 159 patients between 2016 and 2021 at 23 UK hospitals from Aberdeen to Colchester, led from the Churchill Cancer Centre in Oxford. After induction gemcitabine and nab-paclitaxel, patients were randomised between standard and high-dose capecitabine-based chemoradiotherapy with or without nelfinavir; the registry lists the trial as completed on 23 June 2021 with progression-free survival and overall survival as primary outcomes. No primary publication was found in Europe PMC on 24 September 2026, so the corpus records the design and status only; with LAP07 and CONKO-007 it is the evidence base for the locally advanced row's statement that chemoradiotherapy is optional.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites), Capecitabine, IMRT / IGRT (modern external beam).
Shares Gemcitabine + nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites).
Shares Gemcitabine + nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites).
Shares Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites), IMRT / IGRT (modern external beam).
Shares Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites), IMRT / IGRT (modern external beam).
Shares Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites), IMRT / IGRT (modern external beam).
Shares Gemcitabine + nab-paclitaxel, Cancer Research UK, Pancreatic cancer trials open today (registry snapshot and UK sites), Pancreatic ductal adenocarcinoma.
Shares Gemcitabine + nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites).
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