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A phase 2 trial of sintilimab and tegafur, gimeracil and oteracil (S-1) in pancreatic cancer, run by Ruijin Hospital, not yet recruiting.
Safety and Efficacy of Multimodal Thermal Therapy (MTT) Combined With KRAS G12V mRNA Vaccine, S-1, and Sintilimab in Patients With Metastatic Pancreatic Cancer is a phase 2, interventional study registered as NCT07745790 by Ruijin Hospital, with a registry enrolment figure of 20 participants, started 2026-07-13 and due to reach its primary completion in 2029-07-31. Interventions recorded: Multimodal Thermal Therapy (MTT) System; KRAS G12V mRNA Vaccine; Sintilimab; S-1. Conditions listed: Pancreatic Ductal Adenocarcinoma; Liver Neoplasms; Lung Neoplasms. Primary outcome: Incidence and Severity of Adverse Events (CTCAE v6.0); Frequency of Dose Modifications and Treatment Discontinuations. Pancreatic eligibility wording from the registry: "* Patients with advanced pancreatic cancer or postoperative recurrent pancreatic cancer confirmed by histopathological or cytological examination". Sites: China. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Sintilimab, Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma, Immune checkpoint inhibitors and the tag pancreatic-deep-dive.
Shares Sintilimab, Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma, Cytotoxic chemotherapy and the tag pancreatic-deep-dive.
Shares Sintilimab, Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma, Immune checkpoint inhibitors and the tag pancreatic-deep-dive.
Shares Tegafur, gimeracil and oteracil (S-1), Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma, Cytotoxic chemotherapy and the tag pancreatic-deep-dive.
Shares Sintilimab, Pancreatic cancer trials open today (registry snapshot and UK sites), Cytotoxic chemotherapy, Immune checkpoint inhibitors and the tag pancreatic-deep-dive.
Shares Sintilimab, Pancreatic cancer trials open today (registry snapshot and UK sites), Cytotoxic chemotherapy, Immune checkpoint inhibitors and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma, Cytotoxic chemotherapy, Immune checkpoint inhibitors and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma, Immune checkpoint inhibitors and the tag pancreatic-deep-dive.
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