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A phase 1/2 trial in colorectal cancer, run by SOTIO Biotech a.s., now recruiting.
A Study to Assess Safety and Efficacy of SOT109 in Patients With Advanced Unresectable or Metastatic Colorectal Cancer is a phase 1/2, randomised interventional study registered as NCT07693751 by SOTIO Biotech a.s., with a registry enrolment figure of 100 participants, started 2026-08-12 and due to reach its primary completion in 2027-11-29. Interventions recorded: SOT109. Conditions listed: Colorectal Cancer (Locally Advanced or Metastatic). Primary outcome: Part A: Maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of SOT109; Part B: Optimal dose of SOT109 for subsequent clinical trials; Part B: Objective Response Rate (ORR) of SOT109. Colorectal eligibility wording from the registry: "* Direct (conjugated) bilirubin is within normal limits (≤ULN), and". Sites: Moldova, United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
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