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A phase 1/2 trial of ivonescimab in colorectal cancer, run by Akeso, not yet recruiting.
A Study of AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases is a phase 1/2, randomised interventional study registered as NCT07357220 by Akeso, with a registry enrolment figure of 72 participants, started 2026-03-02 and due to reach its primary completion in 2027-02-28. Interventions recorded: VG2025; AK112. Conditions listed: Colorectal Cancer With Hepatic Metastases. Primary outcome: Number of participants experiencing dose-limiting toxicities (DLTs); Number of participants with adverse events (AEs) and severity; Objective Response Rate (ORR). Colorectal eligibility wording from the registry: "Histologically or cytologically confirmed unresectable colorectal cancer with liver metastases; adenocarcinoma type". Sites: China. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Ivonescimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Akeso, Ivonescimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Ivonescimab, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer, Immune checkpoint inhibitors and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer, Immune checkpoint inhibitors and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer, Immune checkpoint inhibitors and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer, Immune checkpoint inhibitors and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot), Rectal cancer, Immune checkpoint inhibitors and the tag colorectal-deep-dive.
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