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A phase 1/2 trial of fluorouracil (5-FU), fOLFIRI (5-FU, leucovorin, irinotecan), leucovorin (folinic acid) and cAPOX (capecitabine, oxaliplatin) in pancreatic cancer, run by Roswell Park Cancer Institute, now recruiting.
Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma is a phase 1/2, interventional study registered as NCT07214298 by Roswell Park Cancer Institute, with a registry enrolment figure of 35 participants, started 2026-02-16 and due to reach its primary completion in 2028-02-16. Interventions recorded: Biopsy Procedure; Biospecimen Collection; Computed Tomography; Fluorouracil; Irinotecan; Leucovorin Calcium; Magnetic Resonance Imaging; Oxaliplatin; Pegcetacoplan. Conditions listed: Metastatic Pancreatic Ductal Adenocarcinoma; Stage IV Pancreatic Cancer AJCC v8. Primary outcome: Incidence of treatment-related adverse events (AE) (Phase I); Progression-free survival (Phase II). Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Fluorouracil (5-FU), Pancreatic cancer trials open today (registry snapshot and UK sites) and the tag pancreatic-deep-dive.
Shares Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Fluorouracil (5-FU), Pancreatic cancer trials open today (registry snapshot and UK sites) and the tag pancreatic-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Fluorouracil (5-FU) and the tag pancreatic-deep-dive.
Shares Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Fluorouracil (5-FU), Pancreatic cancer trials open today (registry snapshot and UK sites) and the tag pancreatic-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Fluorouracil (5-FU) and the tag pancreatic-deep-dive.
Shares Fluorouracil (5-FU), Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma, Cytotoxic chemotherapy and the tag pancreatic-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), CAPOX (capecitabine, oxaliplatin), Fluorouracil (5-FU), Pancreatic cancer trials open today (registry snapshot and UK sites) and the tag pancreatic-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), CAPOX (capecitabine, oxaliplatin), Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
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