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A phase 2 trial of leucovorin (folinic acid), fOLFIRI (5-FU, leucovorin, irinotecan), fruquintinib and bevacizumab (glioblastoma use) in colorectal cancer, run by Federation Francophone de Cancerologie Digestive, not yet recruiting.
Second-line Doublet Chemotherapy (FOLFOX or FOLFIRI) Plus Fruquintinib Versus Doublet Chemotherapy (FOLFOX or FOLFIRI) Plus Bevacizumab in Metastatic Colorectal Cancer is a phase 2, randomised interventional study registered as NCT07150403 by Federation Francophone de Cancerologie Digestive, with a registry enrolment figure of 74 participants, started 2025-12-31 and due to reach its primary completion in 2028-02-28. Interventions recorded: Oxaliplatin intravenous; 5 FU bolus; Folinic acid; 5 FU continuous; Irinotecan; FRUQUINTINIB; BEVACIZUMAB. Conditions listed: Metastatic Colorectal Carcinoma (mCRC). Primary outcome: Disease Control Rate (DCR). Colorectal eligibility wording from the registry: "* Patients with a histologically confirmed diagnosis of metastatic colorectal cancer (mCRC), with a documented disease progression (as per RECIST v1". Sites: France. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Fruquintinib, FOLFIRI (5-FU, leucovorin, irinotecan), Anti-angiogenic therapy, Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares Fruquintinib, Bevacizumab (glioblastoma use), Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Fruquintinib, Bevacizumab (glioblastoma use), Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Bevacizumab (glioblastoma use), FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares Bevacizumab (glioblastoma use), FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Anti-angiogenic therapy, Topoisomerase-I inhibitors (and ADC payloads), Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Fruquintinib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Fruquintinib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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