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A phase 3 trial of JMT101, fOLFIRI (5-FU, leucovorin, irinotecan) and regorafenib in colorectal cancer, run by Shanghai JMT-Bio Inc., not yet recruiting.
The Study of JMT101 Combined With Irinotecan as a ≥3rd-Line Treatment in Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT07134205 by Shanghai JMT-Bio Inc., with a registry enrolment figure of 252 participants, started 2025-10-01 and due to reach its primary completion in 2027-06-01. Interventions recorded: JMT101; Irinotecan; Regorafenib. Conditions listed: Metastatic Colorectal Cancer (mCRC). Primary outcome: Progression-free Survival (PFS). Colorectal eligibility wording from the registry: "Pathological diagnosis as metastatic colorectal adenocarcinoma, with RAS and BRAF wild-type and non-dMMR/MSI-H;". No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Regorafenib, FOLFIRI (5-FU, leucovorin, irinotecan), Anti-angiogenic therapy, Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Anti-angiogenic therapy, Topoisomerase-I inhibitors (and ADC payloads), Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Regorafenib, Mismatch-repair deficient (MSI-high) colorectal cancer, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Regorafenib, Mismatch-repair deficient (MSI-high) colorectal cancer, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Regorafenib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Regorafenib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Regorafenib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Regorafenib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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