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A phase 3 trial of fluorouracil (5-FU), gemcitabine, fOLFIRI (5-FU, leucovorin, irinotecan), fLOT (5-FU, leucovorin, oxaliplatin, docetaxel) and other drugs in pancreatic cancer, run by SWOG Cancer Research Network, now recruiting.
Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations is a phase 3, randomised interventional study registered as NCT06998940 by SWOG Cancer Research Network, with a registry enrolment figure of 94 participants, started 2026-05-13 and due to reach its primary completion in 2029-12-31. Interventions recorded: Biospecimen Collection; Computed Tomography; Fluorouracil; Gemcitabine; Irinotecan; Irinotecan Sucrosofate; Leucovorin; Nab-paclitaxel; Panitumumab; Questionnaire Administration. Conditions listed: Locally Advanced Pancreatic Adenocarcinoma; Metastatic Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma. Primary outcome: Overall survival (OS). Pancreatic eligibility wording from the registry: "* Participants must have a histologically or cytologically confirmed diagnosis of ductal adenocarcinoma of the pancreas". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), FOLFIRI (5-FU, leucovorin, irinotecan), Nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), Nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma, Fluorouracil (5-FU) and the tag pancreatic-deep-dive.
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), FOLFIRI (5-FU, leucovorin, irinotecan), Nab-paclitaxel, Fluorouracil (5-FU) and the tag pancreatic-deep-dive.
Shares Nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites), Gemcitabine and the tag pancreatic-deep-dive.
Shares Nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites), Gemcitabine and the tag pancreatic-deep-dive.
Shares Nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic cancer trials open today (registry snapshot and UK sites), Gemcitabine and the tag pancreatic-deep-dive.
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), FOLFIRI (5-FU, leucovorin, irinotecan), Nab-paclitaxel, Fluorouracil (5-FU) and the tag pancreatic-deep-dive.
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), Locally advanced unresectable pancreatic ductal adenocarcinoma, Fluorouracil (5-FU), Pancreatic cancer trials open today (registry snapshot and UK sites) and the tag pancreatic-deep-dive.
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