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A phase 2 trial of cemiplimab and fianlimab in lung cancer, run by Montefiore Medical Center, now recruiting.
Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer is a phase 2, interventional study registered as NCT06865339 by Montefiore Medical Center, with a registry enrolment figure of 76 participants, started 2025-08-07 and due to reach its primary completion in 2027-08. Interventions recorded: Cemiplimab; Fianlimab; Radiotherapy; Platinum Doublet Chemotherapy (PDC). Conditions listed: NSCLC; Locally Advanced. Primary outcome: Objective Response Rate (ORR) to induction IO therapy. Lung eligibility wording from the registry: "* Previously untreated and biopsy-proven NSCLC, with measurable disease (at least 1 unidimensional, radiographically measurable lesion based on RECIST v1". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Regeneron, Unresectable stage III non-small-cell lung cancer, Cemiplimab, Lung cancer trials open today (registry snapshot) and the tag lung-deep-dive.
Shares Regeneron, Cemiplimab, Lung cancer trials open today (registry snapshot), Immune checkpoint inhibitors and the tag lung-deep-dive.
Shares Regeneron, Cemiplimab, Lung cancer trials open today (registry snapshot), Immune checkpoint inhibitors and the tag lung-deep-dive.
Shares Unresectable stage III non-small-cell lung cancer, Lung cancer trials open today (registry snapshot), IMRT / IGRT (modern external beam), Immune checkpoint inhibitors and the tag lung-deep-dive.
Shares Regeneron, Cemiplimab, Lung cancer trials open today (registry snapshot), Immune checkpoint inhibitors and the tag lung-deep-dive.
Shares Regeneron, Cemiplimab, Lung cancer trials open today (registry snapshot), Immune checkpoint inhibitors and the tag lung-deep-dive.
Shares Unresectable stage III non-small-cell lung cancer, Lung cancer trials open today (registry snapshot), IMRT / IGRT (modern external beam) and the tag lung-deep-dive.
Shares Unresectable stage III non-small-cell lung cancer, Lung cancer trials open today (registry snapshot), IMRT / IGRT (modern external beam) and the tag lung-deep-dive.
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