Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT06802666 by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, with a registry enrolment figure of 45 participants, started 2024-10-16 and due to reach its primary completion in 2026-09-01. Interventions recorded: short-course radiotherapy; Ivonescimab; capecitabine; oxaliplatin; TME surgery. Conditions listed: Locally Advanced Rectal Cancer; Neoadjuvant Therapy. Primary outcome: Pathologic complete response rate (pCR). Colorectal eligibility wording from the registry: "Histopathologically confirmed locally advanced rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.