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A phase 2 trial in colorectal cancer, run by National Cancer Institute (NCI), now recruiting.
An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis is a phase 2, interventional study registered as NCT06557733 by National Cancer Institute (NCI), with a registry enrolment figure of 38 participants, started 2026-03-31 and due to reach its primary completion in 2027-06-30. Interventions recorded: Biopsy Procedure; Biospecimen Collection; EP2/EP4 Antagonist TPST-1495; Esophagogastroduodenoscopy; Gastrointestinal Endoscopy; Questionnaire Administration. Conditions listed: Colorectal Carcinoma; Familial Adenomatous Polyposis. Primary outcome: Percent change in duodenal polyp burden; Incidence of adverse events. Colorectal eligibility wording from the registry: "* Clinical diagnosis of classic FAP with ≥ 100 colorectal adenomas status post colectomy or a sub-total colectomy and a family history of FAP". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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