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Trials
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

A phase 3 trial of Carboplatin and Temozolomide in glioma & glioblastoma, run by CarThera, now recruiting.

Recruiting

Also called: SONOBIRD

Overview Taking part Connected8

Overview

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM is a phase 3 interventional study registered as NCT05902169 by CarThera, with 560 participants planned, started 2024-01-29 and due to reach its primary completion in 2028-01-28. Interventions recorded: SonoCloud-9 (SC9), Carboplatin, Lomustine and Temozolomide.

Setting

A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma.

Phase

Phase 3

Sponsor

CarThera

Registry

Started

2024-01-29

Enrolled

560 enrolled

Taking part

NCT05902169recruiting

Run by: CarThera
Open to: 18 Years and over, any sex
Enrolment: 560 (estimated)
Sites: 56, 53 recruiting
Countries: Austria, Belgium, Denmark, France, Germany, Italy, Netherlands, Spain, Sweden, Switzerland, United States
Registry updated: 2026-10-05

The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.

ClinicalTrials.gov data courtesy of the US National Library of Medicine.

Connected

8

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cancers

Glioma & glioblastoma

technologies

Cytotoxic chemotherapy Platinum agents Transcranial focused ultrasound systems (Exablate Neuro, SonoCloud)

drugs

ApprovedCytotoxic chemotherapy (platinum)

ApprovedOral alkylating chemotherapy

Temozolomide · Temodar

companies

ideas

A skull ultrasound implant that opens the barrier at every cycle

Evidence strength49/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
560 enrolled+14
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

Make correction

Report a readout

Cancers

Glioma & glioblastoma

Technologies

Cytotoxic chemotherapy
Platinum agents
Transcranial focused ultrasound systems (Exablate Neuro, SonoCloud)

Products

Carboplatin
Temozolomide

Companies

Carthera

Sources

Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.

ClinicalTrials.gov · 1

ClinicalTrials.gov NCT05902169

A source that has moved or gone is reported by the weekly link check. /audit/

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sourced, not expert-reviewed

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct05902169.

WebMCP tools registered on this page: onco_search, onco_get_entity.