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A phase 2 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) and FOLFOXIRI in colorectal cancer, run by Sun Yat-sen University, now recruiting.
Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 in Locally Advanced Colorectal Cancer is a phase 2, randomised interventional study registered as NCT05571644 by Sun Yat-sen University, with a registry enrolment figure of 143 participants, started 2023-07-10 and due to reach its primary completion in 2025-12-31. Interventions recorded: mFOLFOXIRI + Cadonilimab; mFOLFOX6; mFOLFOXIRI; mFOLFOXIRI+AK104+fruquintinib. Conditions listed: Colorectal Cancer. Primary outcome: Pathological complete response (pCR) rates. Colorectal eligibility wording from the registry: "Colorectal adenocarcinoma with definite histological evidence;". Sites: China. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
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