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Trials
Study of Sacituzumab Govitecan (SG) in Japanese Participants With Advanced Solid Tumors

Study of Sacituzumab Govitecan (SG) in Japanese Participants With Advanced Solid Tumors

A phase 1/2 trial of Sacituzumab govitecan in triple-negative breast cancer and bladder & urothelial cancer, run by Gilead Sciences, active and no longer recruiting.

Active

Also called: ASCENT-J02

Overview Taking part Key papers1 Connected7

Overview

Study of Sacituzumab Govitecan (SG) in Japanese Participants With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT05101096 by Gilead Sciences, with 135 participants enrolled, started 2021-10-20 and due to reach its primary completion in 2027-05. Interventions recorded: Sacituzumab Govitecan-hziy.

Setting

A Phase 1/2 Open-Label Study of Sacituzumab Govitecan in Japanese Patients With Advanced Solid Tumors (ASCENT-J02)

Phase

Phase 1/2

Sponsor

Gilead Sciences

Registry

Started

2021-10-20

Enrolled

135 enrolled

Taking part

NCT05101096active not recruiting

Run by: Gilead Sciences
Open to: 18 Years and over, any sex
Enrolment: 135
Sites: 36
Countries: Japan
Registry updated: 2026-07-10

The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.

ClinicalTrials.gov data courtesy of the US National Library of Medicine.

Key papers

1

observationalInternational journal of clinical oncology 202411 citations

Preliminary results from ASCENT-J02: a phase 1/2 study of sacituzumab govitecan in Japanese patients with advanced solid tumors

This is the paper Europe PMC returns for registry id NCT05101096 with the most citations, so it is the natural first reading for anyone following the ASCENT-J02 trial. Read the abstract above alongside the trial page and the registry entry; the record was linked automatically and its figures have not been checked by hand.

Connected

7

Similar pages

Trial
A Study of Sacituzumab Govitecan Given at an Alternative Dose and Schedule in Participants With Advanced Triple-Negative Breast Cancer
Shares Gilead Sciences (incl. Kite), Sacituzumab govitecan, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC) and the tag pipeline.
Trial
Study of Sacituzumab Govitecan in Participants With Metastatic Solid Tumors
Shares Gilead Sciences (incl. Kite), Sacituzumab govitecan, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC) and the tag pipeline.
Trial
Study of Sacituzumab Govitecan in Patients With Solid Tumor
Shares Gilead Sciences (incl. Kite), Sacituzumab govitecan, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC) and the tag pipeline.
Trial
Study of Sacituzumab Govitecan in Chinese Patients With Metastatic Triple-negative Breast Cancer Who Received at Least Two Prior Treatments
Shares Gilead Sciences (incl. Kite), Sacituzumab govitecan, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC) and the tag pipeline.
Trial
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
Shares Gilead Sciences (incl. Kite), Sacituzumab govitecan, Topoisomerase-I inhibitors (and ADC payloads), Bladder & urothelial cancer and the tag pipeline.
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Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy
Shares Gilead Sciences (incl. Kite), Sacituzumab govitecan, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC) and the tag pipeline.
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Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)
Shares Gilead Sciences (incl. Kite), Sacituzumab govitecan, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC) and the tag pipeline.
Trial
Asian Study of Sacituzumab Govitecan (IMMU-132) in HR+/HER2- Metastatic Breast Cancer (MBC)
Shares Gilead Sciences (incl. Kite), Sacituzumab govitecan, Topoisomerase-I inhibitors (and ADC payloads), Antibody-drug conjugate (ADC) and the tag pipeline.

cancers

Bladder & urothelial cancer Triple-negative breast cancer (TNBC)

technologies

Antibody-drug conjugate (ADC)Topoisomerase-I inhibitors (and ADC payloads)

drugs

ApprovedADC

Sacituzumab govitecan · Trodelvy

companies

Gilead Sciences (incl. Kite)

key papers

Preliminary results from ASCENT-J02: a phase 1/2 study of sacituzumab govitecan in Japanese patients with advanced solid tumors

Evidence strength24/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
135 enrolled+11
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

Make correction

Report a readout

Cancers

Triple-negative breast cancer (TNBC)
Bladder & urothelial cancer

Technologies

Antibody-drug conjugate (ADC)
Topoisomerase-I inhibitors (and ADC payloads)

Products

Sacituzumab govitecan

Companies

Gilead Sciences (incl. Kite)

Sources

Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.

ClinicalTrials.gov · 1

ClinicalTrials.gov NCT05101096

A source that has moved or gone is reported by the weekly link check. /audit/

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sourced, not expert-reviewed

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