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A phase 2 trial of fluorouracil, leucovorin and liposomal irinotecan in gallbladder cancer and other biliary tract cancers, run by Georgetown University, active and no longer recruiting.
NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary Cancer is a phase 2 interventional study registered as NCT04005339 by Georgetown University, with a registry enrolment figure of 48 participants, started 2019-07-29 and due to reach its primary completion in 2025-09-03. Interventions recorded: Nanoliposomal Irinotecan, Leucovorin, Fluorouracil. Conditions listed: Advanced Biliary Tract Cancer. Gallbladder cancer is named in the registry entry: "* Pathologically-confirmed biliary tract cancer (cholangiocarcinoma or gallbladder adenocarcinoma), unresectable or metastatic". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Liposomal irinotecan, Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups), Biliary tract cancer (all types), Fluorouracil (5-FU) and the tag gallbladder-deep-dive.
Shares Liposomal irinotecan, Leucovorin (folinic acid), Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups), Biliary tract cancer (all types) and the tag gallbladder-deep-dive.
Shares Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups), Biliary tract cancer (all types), Fluorouracil (5-FU), Biliary tract cancer (cholangiocarcinoma) and the tag gallbladder-deep-dive.
Shares Liposomal irinotecan, Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups), Biliary tract cancer (all types), Fluorouracil (5-FU) and the tag gallbladder-deep-dive.
Shares Liposomal irinotecan, Leucovorin (folinic acid), Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups), Fluorouracil (5-FU) and the tag gallbladder-deep-dive.
Shares Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups), Biliary tract cancer (all types), Biliary tract cancer (cholangiocarcinoma), Gallbladder cancer and the tag gallbladder-deep-dive.
Shares Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups), Biliary tract cancer (all types), Biliary tract cancer (cholangiocarcinoma), Gallbladder cancer and the tag gallbladder-deep-dive.
Shares Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups), Biliary tract cancer (all types), Biliary tract cancer (cholangiocarcinoma), Gallbladder cancer and the tag gallbladder-deep-dive.
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