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A phase 3 trial of FOLFOXIRI and cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Sun Yat-sen University, now recruiting.
Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation is a phase 3, randomised interventional study registered as NCT03671252 by Sun Yat-sen University, with a registry enrolment figure of 776 participants, started 2018-11-16 and due to reach its primary completion in 2025-09-25. Interventions recorded: FOLFOXIRI; XELOX; Chemoradiotherapy; TME operation; efficacy evaluation. Conditions listed: Rectal Cancer. Primary outcome: 3-year disease free survival rate. Colorectal eligibility wording from the registry: "* 2）Histological diagnosis of rectal adenocarcinoma;". Sites: China. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), CAPOX (capecitabine, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), CAPOX (capecitabine, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan), CAPOX (capecitabine, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
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