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A phase 1/2 trial in pancreatic cancer, run by M.D. Anderson Cancer Center, now recruiting.
iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation is a phase 1/2, interventional study registered as NCT03608631 by M.D. Anderson Cancer Center, with a registry enrolment figure of 28 participants, started 2021-01-27 and due to reach its primary completion in 2027-04-30. Interventions recorded: Mesenchymal Stromal Cells-derived Exosomes with KRAS G12D siRNA. Conditions listed: KRAS NP_004976.2:p.G12D; Metastatic Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Stage IV Pancreatic Cancer AJCC v8. Primary outcome: Maximum Tolerated Dose Determined by Dose Limiting Toxicity; Minimal residual disease rate in high-risk patients; Overall survival (OS). Pancreatic eligibility wording from the registry: "* Patients with histologically confirmed metastatic pancreatic ductal adenocarcinoma harboring KrasG12D mutation". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Metastatic pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
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