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A phase 1/2 trial of cyclophosphamide, fludarabine and aldesleukin (high-dose IL-2) in pancreatic cancer, run by National Cancer Institute (NCI), now recruiting.
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients is a phase 1/2, interventional study registered as NCT03190941 by National Cancer Institute (NCI), with a registry enrolment figure of 110 participants, started 2017-09-21 and due to reach its primary completion in 2027-06-29. Interventions recorded: Cyclophosphamide; Fludarabine; Anti-KRAS G12V mTCR PBL; Aldesleukin. Conditions listed: Pancreatic Cancer; Gastric Cancer; Gastrointestinal Cancer; Colon Cancer; Rectal Cancer. Primary outcome: Response rate; Frequency and severity of treatment-related adverse events. Pancreatic eligibility wording from the registry: "* Patients with pancreatic cancer must have received gemcitabine, 5FU, and oxaliplatin (or similar agents), or have contraindications to receiving those medications". Sites: United States. No results are recorded here; the registry entry is the source.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Aldesleukin (high-dose IL-2), Fludarabine, Cyclophosphamide, Pancreatic cancer trials open today (registry snapshot and UK sites) and the tag pancreatic-deep-dive.
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Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Pancreatic cancer trials open today (registry snapshot and UK sites), Pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
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