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A phase 1/2 trial of Olaparib and Bevacizumab in ovarian cancer, small-cell lung cancer and gastric & gastro-oesophageal junction cancer, run by AstraZeneca, active and no longer recruiting.
A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors. is a phase 1/2 interventional study registered as NCT02734004 by AstraZeneca, with 264 participants enrolled, started 2016-03-17 and due to reach its primary completion in 2021-09-17. Interventions recorded: Olaparib, MEDI4736 and Bevacizumab. Results have been posted on the registry.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
264 enrolled.
Figures from the ClinicalTrials.gov results section (first posted 2023-10-13), not from a publication
Source95% CI 81.12 to 97.82; Figures from the ClinicalTrials.gov results section (first posted 2023-10-13), not from a publication
SourceFigures from the ClinicalTrials.gov results section (first posted 2023-10-13), not from a publication
Source| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Initial Stage Cohorts: Disease Control Rate (DCR) at Week 12primary | Initial Stage: Small Cell Lung Cancer | 38 | 28.9% | - | - | link |
| Initial Stage: Breast Cancer | 30 | 80% | ||||
| Initial Stage: Ovarian Cancer | 32 | 81.3% | ||||
| Initial Stage: Gastric Cancer | 39 | 25.6% | ||||
| Second Stage Cohort: Objective Response Rate (ORR)primary | Second Stage: Ovarian Cancer Expansion | 51 | 92.2% | - | - | link |
| Second Stage Cohorts: DCR at Week 24primary | Second Stage: Ovarian Cancer Triplet | 31 | 74.2% | - | - | link |
| Second Stage: Ovarian Cancer Doublet | 32 | 28.1% |
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
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Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/