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Trials
Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer

Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer

A phase 3 trial of Glufosfamide in pancreatic ductal adenocarcinoma, run by Eleison Pharmaceuticals LLC., now recruiting.

Recruiting

Overview Taking part Connected5

Overview

Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer is a phase 3 interventional study registered as NCT01954992 by Eleison Pharmaceuticals LLC., with 480 participants planned, started 2014-04 and due to reach its primary completion in 2026-06. Interventions recorded: Glufosfamide and Fluorouracil.

Setting

A Randomized Phase 3 Study of the Efficacy and Safety of Glufosfamide Compared With Fluorouracil (5-FU) in Patients With Metastatic Pancreatic Adenocarcinoma Previously Treated With Gemcitabine

Phase

Phase 3

Sponsor

Eleison Pharmaceuticals LLC.

Registry

Started

2014-04

Enrolled

480 enrolled

Taking part

NCT01954992recruiting

Run by: Eleison Pharmaceuticals LLC.
Open to: 18 Years and over, any sex
Enrolment: 480 (estimated)
Sites: 3, 3 recruiting
Countries: United States
Registry updated: 2026-10-07

The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.

ClinicalTrials.gov data courtesy of the US National Library of Medicine.

Connected

5

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cancers

Metastatic pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma

technologies

Cytotoxic chemotherapy

drugs

ApprovedFluoropyrimidine antimetabolite

Fluorouracil (5-FU) · Adrucil / Efudex

ApprovedNucleoside analogue (deoxycytidine)

Gemcitabine · Gemzar / Infugem

Evidence strength48/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
480 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

Make correction

Report a readout

Cancers

Pancreatic ductal adenocarcinoma
Metastatic pancreatic ductal adenocarcinoma

Technologies

Cytotoxic chemotherapy

Products

Fluorouracil (5-FU)
Gemcitabine

Sources

Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.

ClinicalTrials.gov · 1

ClinicalTrials.gov NCT01954992

A source that has moved or gone is reported by the weekly link check. /audit/

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sourced, not expert-reviewed

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