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Brought immunotherapy to nasopharyngeal cancer, an Epstein-Barr-virus-driven cancer common in southern China, and won the first US approval for that disease.
JUPITER-02, trial NCT03581786 sponsored by Junshi and Coherus and reported in 2021, brought immunotherapy to nasopharyngeal carcinoma, an Epstein-Barr-virus-driven cancer common in southern China, and won the first US approval for that disease. It randomised 289 patients with untreated recurrent or metastatic disease to toripalimab or placebo with gemcitabine and cisplatin, met its primary progression-free survival endpoint with a large effect, and confirmed an overall survival benefit with six-year follow-up showing sustained separation, leading to FDA approval on 27 October 2023 and EU approval after. OnCo links it to head and neck cancer, PD-1 as a target, toripalimab, Sun Yat-sen University Cancer Center, Jun Ma and Shanghai Junshi Biosciences. Whether plasma EBV DNA can guide who needs the immunotherapy is the open question.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Coherus BioSciences, Toripalimab, Immune checkpoint inhibitors.
Shares Coherus BioSciences, Toripalimab, Immune checkpoint inhibitors.
Shares Coherus BioSciences, Toripalimab, Immune checkpoint inhibitors.
Shares Coherus BioSciences, Toripalimab, Immune checkpoint inhibitors.
Shares Shanghai Junshi Biosciences, Toripalimab, Immune checkpoint inhibitors.
Shares Recurrent and metastatic nasopharyngeal carcinoma, Nasopharyngeal carcinoma, Toripalimab, Immune checkpoint inhibitors.
Shares Shanghai Junshi Biosciences, Toripalimab, Immune checkpoint inhibitors.
Shares CAPTAIN-1st, Recurrent and metastatic nasopharyngeal carcinoma.
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