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The American Ewing sarcoma regimen beat the European one in a head-to-head trial, unifying practice.
Euro Ewing 2012, trial NCT00987636 sponsored by the University of Birmingham and the EuroEwing consortium and published in JCO in 2023, showed that the American Ewing sarcoma regimen, VDC/IE, beat the European VIDE/VAI regimen in a head-to-head trial, unifying practice. It randomised 640 newly diagnosed patients and found better event-free and overall survival with VDC/IE, with less toxicity and a shorter treatment duration, making it the international standard. OnCo links it to sarcomas, doxorubicin, ifosfamide, Douglas S. Hawkins, Uta Dirksen, the Children's Cancer and Leukaemia Group, SIOP Europe and the bottleneck of rare and paediatric cancers without markets. Whether further intensification or new agents can improve on VDC/IE is the open question.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Ifosfamide, Doxorubicin, Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy.
Shares Ifosfamide, Doxorubicin, Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy.
Shares SIOP Europe (European Society for Paediatric Oncology), Ifosfamide, Rare and paediatric cancers without markets, Doxorubicin.
Shares Ifosfamide, Doxorubicin, Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy.
Shares Children's Cancer and Leukaemia Group, SIOP Europe (European Society for Paediatric Oncology), Rare and paediatric cancers without markets.
Shares Ifosfamide, Doxorubicin, Cytotoxic chemotherapy.
Shares Ifosfamide, Doxorubicin, Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy.
Shares SIOP Europe (European Society for Paediatric Oncology), Ifosfamide, Rare and paediatric cancers without markets, Doxorubicin.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/