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Tests CAR-T as frontline consolidation instead of ongoing lenalidomide in patients not having a transplant.
CARTITUDE-5, trial NCT04923893 sponsored by Janssen, tests ciltacabtagene autoleucel as frontline consolidation instead of ongoing lenalidomide maintenance in newly diagnosed myeloma patients for whom transplant is not planned, after bortezomib, lenalidomide and dexamethasone induction. Together with CARTITUDE-6, known as EMagine, which compares cilta-cel with autologous transplant after daratumumab-based induction in transplant-eligible patients, it asks whether one CAR-T infusion can replace transplant or maintenance, and there are no results yet. OnCo links it to multiple myeloma, autologous transplant, cilta-cel, the idea of one CAR-T infusion instead of transplant and the CARTITUDE-4 paper. Whether a single infusion can match years of maintenance is the question it exists to answer.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-07. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares One CAR-T infusion instead of autologous transplant, CARTITUDE-4: cilta-cel CAR-T versus standard combinations after one to three prior lines of myeloma therapy, Ciltacabtagene autoleucel, Johnson & Johnson.
Shares Ciltacabtagene autoleucel, Newly diagnosed multiple myeloma, transplant-eligible, Johnson & Johnson, Multiple myeloma.
Shares Ciltacabtagene autoleucel, Johnson & Johnson, Multiple myeloma.
Shares Ciltacabtagene autoleucel, Johnson & Johnson, Multiple myeloma.
Shares Newly diagnosed multiple myeloma, transplant-ineligible, Newly diagnosed multiple myeloma, transplant-eligible, Multiple myeloma.
Shares Ciltacabtagene autoleucel, Johnson & Johnson, Multiple myeloma.
Shares Newly diagnosed multiple myeloma, transplant-eligible, Johnson & Johnson, Multiple myeloma.
Shares CARTITUDE-4: cilta-cel CAR-T versus standard combinations after one to three prior lines of myeloma therapy, Ciltacabtagene autoleucel, Johnson & Johnson, Multiple myeloma.
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