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Temporarily switching off the ovaries with injections (or removing them) so a premenopausal woman's cancer is starved of oestrogen.
GnRH agonists (goserelin, leuprolide), oophorectomy, or ovarian irradiation. SOFT/TEXT established OFS + aromatase inhibitor for higher-risk premenopausal women; absolute benefit is largest in those under 35 or needing chemotherapy. Required for aromatase inhibitors in premenopausal women, and the likely explanation for chemotherapy's benefit in premenopausal RxPONDER patients.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Showing the molecule this term concerns: Goserelin / leuprolide (ovarian function suppression).
Shares Exemestane, Leuprolide (leuprorelin) and GnRH agonists, Tamoxifen.
Shares Goserelin / leuprolide (ovarian function suppression), Exemestane, Tamoxifen.
Shares Goserelin / leuprolide (ovarian function suppression), Leuprolide (leuprorelin) and GnRH agonists.
Shares Menopause brought on by cancer treatment, and the options for it, Exemestane, Tamoxifen, HR-positive / HER2-negative breast cancer.
Shares Menopause brought on by cancer treatment, and the options for it, Bone loss caused by cancer treatment, and what rebuilds it, Exemestane, Tamoxifen.
Shares Exemestane, Tamoxifen.
Shares SOFT & TEXT, HR-positive / HER2-negative breast cancer.
Shares Exemestane, Tamoxifen.
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