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A protein that speeds up a specific chemical reaction by binding its substrate in an active-site pocket. Kinases, PARP and topoisomerases are enzymes and drug targets, because a small molecule lodged in the active site stops the reaction.
Enzymes bind their substrate in a pocket called the active site, convert it, and release the product thousands of times per second. Kinases, which attach phosphate groups, and PARP, which helps repair DNA, are enzymes; so are topoisomerases, which untangle DNA and are the targets of several chemotherapy drugs and ADC payloads. Small-molecule inhibitors usually work by lodging in the active site so the natural substrate cannot enter.
In plain words · PARP inhibitors block DNA repair. Some cancers with defective repair are especially vulnerable, but the gene, disease setting and treatment combination determine which evidence applies.
Showing the target this term concerns: PARP.
Shares Phosphorylation, Kinase.
Shares PARP, Pancreatic ductal adenocarcinoma.
Shares PARP, Pancreatic ductal adenocarcinoma.
Shares PARP, Pancreatic ductal adenocarcinoma.
Shares Phosphorylation, Kinase.
Shares PARP, Pancreatic ductal adenocarcinoma.
Shares PARP, Pancreatic ductal adenocarcinoma.