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Discovered regulatory T cells, the immune cells that suppress anti-tumour responses and are now a target for cancer therapy.
Shimon Sakaguchi (Osaka University) identified CD25-positive regulatory T cells in 1995 and demonstrated their role in preventing autoimmunity, a discovery that overturned prevailing dogma and defined a cell type that tumours recruit to escape immune attack. He received the 2025 Nobel Prize in Physiology or Medicine with Mary Brunkow and Fred Ramsdell. His laboratory works on Treg depletion and modulation for cancer immunotherapy.
| Title | Journal | Year |
|---|---|---|
| Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) | Journal of Immunology | 1995 |
| Regulatory T cells and immune tolerance | Cell | 2008 |
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