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This review explains the rise of colorectal cancer in adults under 50, what is known about its causes and distinct features, and how screening ages and clinical management have responded.
Review of the epidemiology of colorectal cancer diagnosed before age 50, including birth-cohort effects, proposed risk factors (obesity, diet, microbiome, antibiotics), clinical and molecular features (left-sided and rectal predominance, later stage at diagnosis, similar mutational profiles in sporadic cases), germline findings, and implications for screening and treatment.
The early-onset colorectal cancer page's emphasis on investigating rectal bleeding at any age, universal germline testing and avoiding treatment escalation on age alone follows this framing.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/