Loading
This study discovered that adenoid cystic carcinomas of the salivary gland and breast are driven by a fusion of the MYB and NFIB genes, providing the defining molecular feature of the tumour and a diagnostic marker.
Molecular study identifying a recurrent t(6;9) translocation in adenoid cystic carcinoma that fuses the MYB oncogene to NFIB, leading to MYB overexpression by loss of microRNA-mediated repression, present in the majority of tumours of both head and neck and breast origin.
MYB immunostaining and MYB-NFIB fusion testing are now diagnostic tools for adenoid cystic carcinoma, and MYB is the principal target of therapeutic research in the disease.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/